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We have increased incidence of acute INH neurotoxicity because of the resurgence of TB in New York City.Others as well may see a similar rise based on local trends in TB infection and disease.Acute INH toxicity should be suspected in children presenting with seizures with or without fever.In patients with a known access to INH,seizures should be considered to be caused by INH toxicity unless proved otherwise.Parenteral pyridoxine,the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increased trends of TB> |
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